Molecular and Cellular MR Imaging

The ability of molecular and cellular imaging to track the survival migration and differentiation of cells in vivo as well as monitor particular gene expression in living subjects is rapidly moving from the research laboratory into daily clinical settings. The interdisciplinary nature of the field mandates a constant dialogue among molecular and cellular biology chemistry physics image analysis and drug discovery to develop and translate promising approaches into reliable scientific applications and viable clinical diagnostic tools.Bringing together a select panel of internationally recognized authors Molecular and Cellular MR Imaging provides a state-of-the-science overview of the multidisciplinary nature of the field and illustrates the application of these various sciences to investigate specific biological processes in animals and humans. Using a systematic organization to present diverse information the text begins with an introductory chapter that defines cellular and molecular imaging and explains why magnetic resonance imaging (MRI) is the most versatile approach for noninvasive in vivo studies. The first section examines the physicochemical principles of various contrast agents including paramagnetic superparamagnetic CEST and PARACEST agents as well as smart and sensing agents. The second section summarizes the wide variety of applications for molecular imaging of genes and of disease states. Contributions cover cancer apoptosis cardiovascular and neurodegenerative disease and the use of pharmacological MRI. The third section is devoted to cellular imaging under a variety of applications and the final section discusses the translational aspects and future directions of cellular and molecular MR imaging.Molecular and Cellular MR Imaging highlights the diversity of skills required to translate advancements in various fields of research into practical applications that promise to revolutionize in vivo imaging as a diagnostic