<p>Sepsis remains a leading cause of morbidity and mortality worldwide underscoring the urgent need for advances in diagnosis prognostication and therapeutic strategies. This Special Issue gathers high-quality contributions exploring the various molecular biomarkers and novel therapeutic approaches aimed at improving outcomes in sepsis. The articles cover a wide spectrum of topics including the identification of early diagnostic indicators molecular pathways driving immune dysregulation host-pathogen interactions and targeted interventions based on biomarker profiles. Both preclinical and clinical studies are included highlighting translational potential and real-world applications. By emphasizing precision medicine and individualized treatment strategies this collection offers valuable insights for clinicians researchers and policy-makers seeking to combat the global burden of sepsis. The findings presented in this Special Issue contribute to a deeper understanding of disease mechanisms and open new avenues for more efficient and personalized sepsis care.</p>
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