<p>The human brain has hundreds of billions of neurons and at least 7 million dendrites have been hypothesized to exist for each neuron with over 100 trillion neuron-neuron neuron-muscle and neuron-endocrine cell synapses [12]. Our body continually receives stimuli from the outer environment and our brain's ability to respond to these stimuli is ensured through synaptic processes motivating the foundations of this Special Issue.</p><p>This reprint aims to underline the role of synaptic plasticity phenomena in our body and clarify the mechanism operated by neurons to guarantee these phenomena. The collection&nbsp;in the Issue comprises 14 papers including 8 reviews and 6 original works one of which is a protocol for differentiating neurons from human stem cells and 5 are preclinical works.</p>
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