MOLECULAR MEDICINES FOR CANCER

<p>The field of molecular medicine covers the medical interventions targeting molecular structures and mechanisms that are involved in disease progression. </p><p>In cancer, several molecular mechanisms have been shown to impact its progression, aggressiveness and chemoresistance. Increasing evidence demonstrates the role of nanotechnology and outcome of molecular therapy.</p><p>Several books have discussed molecular biology and mechanisms involved in cancer, but this text gives an account of molecular therapeutics in cancer relating to advancements of nanotechnology. It provides a description of the multidisciplinary field of molecular medicines and its targeted delivery to cancer using nanotechnology.</p><p>Key Features:</p><li>Provides current information in the multidisciplinary field of molecular medicines and its targeted delivery to cancer using nanotechnology</li><li>Presents important aspects of nanotechnology in the site-specific delivery of anticancer agents</li><li>Includes up to date information on oligonucleotide and gene based therapies in cancer</li><li>Describes small targeted molecules, antibodies and oligonucleotides which have shown to selectively target the molecular structures thereby influencing signal transduction</li><li>Facilitates discussion between researchers involved in cancer therapy and nanoscientists</li> <p><strong>Section I: Nanotechnology-Based Approaches to Target Cancer</strong> 1. Nanomedicines for Cancer 2. Effect of Nanocarrier Size/Surface on Molecular Targeting in Cancer 3. Nanocarrier Systems for Anticancer Drug Delivery at the Subcellular Level 4. Chemo-Resistance Reversal Using Nanomedicines 5. Multifunctional Dendrimers as Cancer Nanomedicines: Peptide-Based Targeting 6. Targeting the Tumor Microenvironment 7. Novel Nanoparticulate Drug Delivery Systems for Active Ingredients of Traditional Chinese Medicine in Cancer Therapy <b>Section II: Imaging Technologies in Cancer </b>8. Noninvasive Imaging in Clinical Oncology: A Testimony of Current Modalities and a Glimpse into the Future 9. Multifunctional Nanocarriers as Theranostic Systems for Targeting Cancer 10. Emerging Nanotechnologies for Cancer Immunodiagnosis and Cancer Immunotherapies <b>Section III: Oligonucleotides and Gene-Based Therapies </b>11. Nucleic Acid Nanotherapeutics 12. Long Non-Coding RNA and Cancer 13. miRNA Therapeutics to Target Multiple Molecular Pathways: Current Status, Challenges, and Future Prospects 14. Alliance of Lipids with siRNA: Opportunities and Challenges for RNAi Therapy 15. Lipid Nanocarriers for RNAi-Based Cancer Therapy 16. Advancements in Polymeric Systems for Nucleic Acid Delivery 17. Self-Assembling Programmable RNA Nanoparticles: From Design and Characterization to Use as an siRNA Delivery Platform 18. DNA Repair and Epigenetics in Cancer 19. Genomic Engineering Utilizing the CRISPR/Cas System and Its Application in Cancer</p>