DENV is the most important factors transmitted by mosquitoes worldwide causing viral disease almost 100 million cases of dangerous DENV each year resulting in severe and life-threatening. However we have not completed a comprehensive outlook of all miRNAs expression regulation target genes through virus-human interactions in patients of DENV. A few human miRNAs might show antiviral miRNAs. When some delusive antiviral miRNAs were blocked by locked nucleic acid-modified antisense oligoribonucleotides the hosts miss carriage to suppress viral replication.