Movement disorders in children

Neuronal migration is a unique process during the development of brain structure. Although cerebral anomalies resulting from impaired migration have been identified for nearly a century most of our knowledge has accumulated in the last decade. Disorders of neuronal migration are causes of mental handicap autism and epilepsy. Many are genetically determined and need precise diagnosis to provide genetic counselling. This book addresses the various aspects of neuronal migration disorders in an ordered way. It will help the clinician to acquire insight as well as proficiency in diagnosis. Individual chapters describe subgroups including lissencephalies subependymal heterotopia non-lissencephalic cortical dysplasias anomalies of the corpus callosum hemimegalencephaly schizencephaly polymicrogyria and multisystem disorders with impaired migration such as chromosomal and metabolic syndromes. Neuroradiological and genetic data are provided with the respective chapters. Although the book is intended for clinical practice it provides core information for all interested in this important biological process.