<p>This reprint aims to provide an overview of the latest research strategies focused on fabricating biomimetic scaffolds to promote tissue regeneration. Biomimicking the microenvironment of the extracellular matrix of a tissue to be healed can be regarded as one of the most promising solutions to obtain a correct physiological regeneration. Materials fabrication techniques cellular and/or biological signals and the incorporation of bioactive compounds are pivotal aspects considered for this purpose. In this reprint experts in the field contribute original research articles review articles and a forward-looking perspective to deliver the current scenario of advancing experimental methodologies used to mimic a tissue-specific extracellular matrix.</p>
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