Multicomponent synthesis of 4H-pyran-3-carboxylate derivatives

A simple versatile one-pot multi-component reaction (MCR) of ethyl 6-amino-5-cyano-2-methyl-4H-pyran-3-carboxylate derivatives has been achieved in the presence of urea as a potent catalyst in water-ethanol as a green solvent system. Reaction was proceeding via three component reaction by utilizing various aldehyde malononitrile and ethylacetoacetate at room temperature. All Synthesized products were confirmed by Mass 1H-NMR IR and Melting point. Mild reaction conditions excellent yields easy isolation of products no column chromatographic separation reusability of reaction media.