Multivariate Biomarker Discovery

Multivariate biomarker discovery is increasingly important in the realm of biomedical research and is poised to become a crucial facet of personalized medicine. This will prompt the demand for a myriad of novel biomarkers representing distinct ''omic'' biosignatures allowing selection and tailoring treatments to the various individual characteristics of a particular patient. This concise and self-contained book covers all aspects of predictive modeling for biomarker discovery based on high-dimensional data as well as modern data science methods for identification of parsimonious and robust multivariate biomarkers for medical diagnosis prognosis and personalized medicine. It provides a detailed description of state-of-the-art methods for parallel multivariate feature selection and supervised learning algorithms for regression and classification as well as methods for proper validation of multivariate biomarkers and predictive models implementing them. This is an invaluable resource for scientists and students interested in bioinformatics data science and related areas.