Nanoceria in Soft Tissue Engineering

Several biocompatible materials have been applied for managing soft tissue lesions; cerium oxide nanoparticles (CNPs or nanoceria) are among the most promising candidates due to their outstanding properties including antioxidant anti-inflammatory antibacterial and angiogenic activities. Much attention should be paid to the physical properties of nanoceria since most of its biological characteristics are directly determined by some of these relevant parameters including the particle size and shape. Nanoceria either in bare or functionalized forms showed the excellent capability of accelerating the healing process of both acute and chronic wounds. The skin heart nervous system and ophthalmic tissues are the main targets of nanoceria-based therapies and the other soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration of soft tissue damage and defects nanoceria-incorporated film hydrogel and nanofibrous scaffolds have been proven to be highly suitable replacements with satisfactory outcomes.