Nanoparticles in Ocular Drug Delivery Systems

<p>Conventional ophthalmic formulations lack prolonged drug release effects and mucoadhesive properties decreasing their residence time in the precorneal area and therefore in drug penetration across ocular tissues presenting a low bioavailability with a consequent reduction in the therapeutic efficacy. These limitations are related to the physiological mechanisms of the eye for example the diluting effect of formulations exerted by the tear fluid constant turnover of the tear fluid blink reflex limited capacity of the conjunctival sac and drainage of formulations applied by gravity.</p><p>To increase the residence time of formulations on the surface of ocular tissues and increase their ability to penetrate these tissues different strategies can be used namely the use of viscosifying agents mucoadhesive polymers stimuli-responsive polymers microparticles and colloidal carriers (e.g. micelles liposomes nanosuspensions nanoemulsions polymeric and lipid nanoparticles). This Special Issue combines the latest research and review works reporting the use of nanoparticles in ophthalmic formulations to increase their bioavailability and improve the therapeutic efficacy of ophthalmic formulations.</p>