NASH and Systemic Complications

<p>Nonalcoholic fatty liver disease (NAFLD) is known as the hepatic manifestation of the metabolic syndrome and while most patients develop simple steatosis up to one-third can develop nonalcoholic steatohepatitis (NASH). NASH is a chronic inflammatory condition of the liver that can further progress to fibrosis and cirrhosis which may eventually lead to liver failure and death. While we have increased our mechanistic knowledge regarding the pathogenesis of NASH within the last decade treatment options are still limited and liver biopsies have remained the gold standard for diagnosis. To achieve major clinical breakthroughs for NASH patients it is not sufficient to use a single animal model since each model has specific limitations. Furthermore we should rely more on alternative models such as organ-on-a-chip which will enable us to explore unknown aspects of disease pathogenesis much faster and serve as clinically relevant surrogates for murine models. Another important direction for the improvement of patient health is to pay more attention to extrahepatic organ-specific and systemic effects which are associated with NASH. The articles in this Special Issue include an up-to-date overview of the rapidly developing technologies novel targets for intervention and insights in the field in NASH. Additionally these articles describe the major challenges in the field strategies to overcome them and suggestions for future directions. To improve patient's outcome clinicians as well as scientists with biomedical nutrition physics and mathematics backgrounds should join forces. Although challenges remain the future of the field seems promising as these novel technologies and developments are expected to lead to progress in NASH.</p>