Neonatal Auto-Immune Thrombocytopenia

Neonatal immunologic thrombocytopenia (NITT) is a serious complication in neonates of women with immunologic thrombocytopenic purpura (ITP). Previous pregnancy with TINN or splenectomy-refractory ITP in the mother have been described as associated with the occurrence of TINN. We have reported five cases in which ITP was already diagnosed in two parturients and neonatal thrombocytopenia was diagnostic in the remaining three. Prenatal treatment of thrombocytopenia with corticosteroids and/or Ig infusion was initiated in three women with a favorable outcome in only one case. Caesarean delivery was used in 4 cases and no post-partum bleeding was observed. For newborns a clinical hemorrhagic syndrome was found in two cases and treatment was based on Ig injections and platelet transfusions for all newborns with a good outcome in 04 cases. Prenatal treatment was based on corticosteroid therapy and/or immunoglobulin infusions to maintain a platelet count above 50 G/L before delivery.