New Classical Propargylic Rearrangements in Natural Products Synthesis

In this book we highlight the strong synthetic potential and scope of transition metal-catalyzed rearrangement reactions for fully economical and complex carbon-carbon bond forming reactions. The Meyer-Schuster and the Rupe rearrangements are emerging as the methods of choice for the homologation of carbonyl compounds into αβ-unsaturated aldehydes and ketones particularly useful for the synthesis of many hindered ketones. The Rautenstrauch-I and Rautenstrauch-II rearrangements of readily propargylic derivatives are very useful reactions for the synthesis of complex cyclopentenones and bicyclo[n.1.0] enol carboxylates in high chemical yields which proceed under mild reaction conditions with high stereoselectivity and total transfer of chirality. In the case of Rautenstrauch-II the basic-methanolysis of the resulting compounds provides bicyclo[n.1.0]ketones valuable building blocks for the preparation of natural products. A reaction mechanism has been advanced and confirmed by experimental evidences which supports the involvement of metallo-carbenes as key species formed through a cyclopropanation event that precedes the 12-acyloxy migration.