New Nitrilimines Their Tandem Generation Cyclizaton And Rearrangement

This book describes the application of 15-electrocyclization and Dimroth rearrangement strategy in the synthesis of novel heterocyclic compounds. The ring systems prepared include pyrazolo[43-e][124]triazolo[43-c]pyrimidine and pyrazolo[43-e][124]triazolo-[15-c]pyrimidine derivatives which are expected to have promising biological activity For example several 3- and/or 5-substituted 7H-pyrazolo[43-e][124]triazolo[43-c]pyrimidines and pyrazolo[43-e][124]triazolo-[15-c]pyrimidine were reported to be potent xanthine oxidase (XO) inhibitors that behave as selective antagonists for human A2A and A3 adenosine receptor subtypes. In addition various of the mentioned derivatives have been used as the new pharmacological tool for characterization of human A3 adenosine receptors. Also a novel series of 124-triazolo[43-a]quinazolin-5(4H)-one and 14-disubstituted-124-triazolo[15-a]quinazolin-5(4H)-one derivatives were prepared using the same methodology of 15-electrocyclization and Dimroth rearrangement.