New route to the synthesis of chiral 124-oxadiazin-5-ones

The research work carried out in this book aims to develop a simple and rapid synthesis route for new chiral derivatives of 124-oxadiazin-5-ones known for their interesting biological activities.The first part of this book describes the synthesis of a series of optically active ?-bromoacids by enantioselective nitrous deamination of natural amino acids. These will subsequently react with thionyl chloride followed by methanol to give the corresponding ?-bromoesters.Condensation of these previously prepared ?-bromoesters with 1-benzenesulfonylpyrrolidin-2-carboxamidoxime in the presence of two equivalents of sodium hydride offers desired new chiral 124-oxadiazin-5-ones in good chemical yields.