New therapeutic compounds against tuberculosis

Tuberculosis (TB) proved to be a controllable preventable and curable disease but it still remains as a leading cause for mortality. Rational Drug Design (RDD) is basically a computer-aided molecular modeling it is an iterative process If it is based on the knowledge of three - dimensional (3-D) structure of the target proteins of interest; it is called “structure based drug design” or “target based drug design”. Such knowledge allows to design molecules capable of binding the receptor so as to maximize the drug affinity and specificity towards the target. Mycolic acid biosynthesis pathway in Mycobacterium tuberculosis was considered a fatal target by designing inhibitors against the enzymes which play a vital role in this pathway.