Human eczema syndrome Atopic dermatitis (AD) is a chronic Pruritic eczematous disease that nearly always begins in childhood and follows a remitting / flaring course that may continue throughout life. It develops as a result of a complex interrelationship of environmental immunologic genetic and pharmacologic factors. It may be exacerbated by infection psychologic stress seasonal / climate changes irritants and allergens. The symptoms of atopic dermatitis are intense itching erythema and sensitivity of the skin that usually becomes worse at night and can disrupt sleep. The exact pathogenesis of atopic dermatitis is unknown. Currently it is believed that IGE- mediated reactions and cellular responses contribute to the chronic inflammation of this disorder. Human eczema syndrome Atopic dermatitis (AD) is a chronic Pruritic eczematous disease that nearly always begins in childhood and follows a remitting / flaring course that may continue throughout life. It develops as a result of a complex interrelationship of environmental immunologic genetic and pharmacologic factors. It may be exacerbated by infection psychologic stress seasonal / climate changes irritants and allergens. The symptoms of atopic dermatitis are intense itching erythema and sensitivity of the skin that usually becomes worse at night and can disrupt sleep. The exact pathogenesis of atopic dermatitis is unknown. Currently it is believed that IGE- mediated reactions and cellular responses contribute to the chronic inflammation of this disorder.