NMR Spectroscopy of Biological Solids

<p>Over the past decade a myriad of techniques have shown that solid-state nuclear magnetic resonance (NMR) can be used in a broad spectrum of applications with exceptionally impressive results. Solid-state NMR results can yield high-resolution details on the structure and function of many important biological solids including viruses fibril-forming molecules and molecules embedded in the cell membrane.</p><p>Filling a void in the current literature <b>NMR Spectroscopy of Biological Solids </b>examines all the recent developments implementation and interpretation of solid-state NMR experiments and the advantages of applying them to biological systems. The book emphasizes how these techniques can be used to realize the structure of non-crystalline systems of any size. It explains how these isotropic and anisotropic couplings interactions are used to determine atomic-level structures of biological molecules in a non-soluble state and extrapolate the three-dimensional structure of membrane proteins using magic-angle spinning (MAS). The book also focuses on the use of multidimensional solid-state NMR methods in the study of aligned systems to provide basic information about the mechanisms of action of a variety of biologically active molecules. </p><p>Addressing principles methods and applications this book provides a critical selection of solid-state NMR methods for solving a wide range of practical problems that arise in both academic and industrial research of biomolecules in the solid state. <b>NMR Spectroscopy of Biological Solids </b>is a forward-thinking resource for students and researchers in analytical chemistry bioengineering material sciences and structural genomics.</p>