Non-Superimposable Approach for Construction of Two Tetrahydrofuran Rings 15-Carbon Chain A Class Of Natural Products C14-C29 Fragment Of The Anticancer Agent Halaven And Laurencia Metabolites

<p>Five membered ring alicyclic compounds are thermodynamically most stable compounds due to their reduced interior angle strain (bond angle is ~108° ideal tetrahedral bond angle 109.5°). The tetrahydrofuran ring being a saturated five membered cyclic ether attracted chemists due to its presence as a main skeleton in several drugs as well as in natural products. For example Eribulin Mesylate Darunavir Azidothymidine etc. are some of the popular drugs bearing a THF unit. Furthermore such THF containing compounds are also widely used in the formulation of several perfumes and flavours.</p><p>Most of the natural products bearing the THF ring as the main skeleton are derived from plant acetogenins. These acetogenins belong to the Annonaceae family (Custard-apple family) and are considered to be the most potent anti-tumor compounds.</p>