Organophosphorus Chemistry 2018

Organophosphorus chemistry is an important discipline within organic chemistry. Phosphorus compounds such as phosphines trialkyl phosphites phosphine oxides (chalcogenides) phosphonates phosphinates and >P(O)H species etc. may be important starting materials or intermediates in syntheses. Let us mention the Wittig reaction and the related transformations the Arbuzov- and the Pudovik reactions the Kabachnik-Fields condensation the Hirao reaction the Mitsunobu reaction etc. Other reactions e.g. homogeneous catalytic transformations or C-C coupling reactions involve P-ligands in transition metal (Pt Pd etc.) complex catalysts. The synthesis of chiral organophosphorus compounds means a continuous challenge. Methods have been elaborated for the resolution of tertiary phosphine oxides and for stereoselective organophosphorus transformations. P-heterocyclic compounds including aromatic and bridged derivatives P-functionalized macrocycles dendrimers and low coordinated P-fragments are also of interest. An important segment of organophosphorus chemistry is the pool of biologically-active compounds that are searched and used as drugs or as plant-protecting agents. The natural analogue of P-compounds may also be mentioned. Many new phosphine oxides phosphinates phosphonates and phosphoric esters have been described which may find application on a broad scale. Phase transfer catalysis ionic liquids and detergents also have connections to phosphorus chemistry. Green chemical aspects of organophosphorus chemistry (e.g. microwave-assisted syntheses solvent-free accomplishments optimizations and atom-efficient syntheses) represent a dynamically developing field. Last but not least theoretical approaches and computational chemistry are also a strong sub-discipline within organophosphorus chemistry.