Overlap syndromes

The overlap syndrome (OS) between autoimmune hepatitis (AIH) primary biliary cholangitis (PBC) and/or primary sclerosing cholangitis (PSC) is a rare and complex syndrome. It represents a real diagnostic and therapeutic challenge.The objectives of this study were to analyze the epidemiological clinical-biological and histological aspects of AIH and SC and to define their evolutionary and prognostic characteristics.Methods: We conducted a retrospective comparative study over a 15-year period including patients treated for AIH (G1) or SC (G2). We collected and compared epidemiological clinical paraclinical therapeutic and evolutionary data.Results: According to our study the diagnosis of pure AIH or in the context of SC is made at a late stage limiting therapeutic options. However immunosuppressive treatment resulted in a complete response in the majority of cases.