Pathogenic Treponema: Molecular and Cellular Biology

In the past Treponema research was severely handicapped because the organisms were notoriously difficult to work with and were unculturable in the laboratory. Powerful molecular and genetic tools developed in recent years have been successfully used to dramatically expand our understanding of treponemal diversity genomics and cellular and molecular biology. Major breakthroughs include sequencing of Treponema genomes and the development of modern molecular methods. In recent years there has been an explosion of new information that is summarized in the current volume. Expert international authors critically review every aspect of the molecular and cellular biology of these fascinating organisms. The focus of this book is on recent advances and new developments in Treponema research in particular those resulting from modern molecular and genetic methodologies. Topics covered include the phylogenic diversity comparative genomics metabolism and cultivation motility antigenic variation immunology of syphilis the use cultivatable treponemes as surrogates for T. pallidum oral treponemes and more. Pathogenic Treponema is essential reading for all scientists and researchers working on trepenomes and other spirochetes and a recommended reference book for all microbiology laboratories.