Pharmaceutical Organic Chemistry II

Analytical synthetic and other evidences in the derivation of structure of benzene Orbital picture resonance in benzene aromatic characters Huckel's rule. Reactions of benzene - nitration sulphonation halogenation reactivity Friedelcrafts alkylation- reactivity limitations Friedelcrafts acylation. Substituents effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction Structure and uses of DDT Saccharin BHC and Chloramine Acidity of phenols effect of substituents on acidity qualitative tests Structure and uses of phenol cresols resorcinol naphthols. Basicity of amines effect of substituents on basicity and synthetic uses of aryl diazonium salts Acidity effect of substituents on acidity and important reactions of benzoic acid. Fatty acids - reactions. b. Hydrolysis Hydrogenation Saponification and Rancidity of oils Drying oils. c. Analytical constants - Acid value Saponification value Ester value Iodine value Acetyl value Reichert Meissl (RM) value - significance and principle involved in their determination Synthesis reactions b. Structure and medicinal uses of Naphthalene Phenanthrene Anthracene Diphenylmethane Triphenylmethane and their derivatives. Baeyer's strain theory limitation of Baeyer's strain theory Coulson and Moffitt's modification Sachse Mohr's theory