PHARMACOLOGY - II

Paul Ehrlich''s concept that protozoal diseases could be cured by the administration ofsynthetic chemicals which selectively react with the target tissue of the protozoa rather thanthat of the host and Domagk''s later expansion of this view to the treatment of bacterialdiseases with the introduction of prontosil were the prominent landmarks in the birth ofmodern chemotherapy. The accuracy and the depth of clinical applications of thesechemotherapeutic agents were further sharpened due to new inventions in the molecularbiology which are increasingly involved to explain the mechanisms of action of many newchemotherapeutic agents. These broad area of pharmacology presented together withnecessary data on the chemistry absorption excretion tolerance and toxicity of the drugsare expected to provide a proper understanding of both the value and limitations of thedrug therapy.