Phosphonation of the C=X Functional Groups Utilizing Alkyl Phosphites

Organophosphorus compounds (OPCs) play an important role in all kinds of life. Phosphate moiety is commonly known to be a part of DNA and RNA backbones. Di- and triphosphates are considered to be the key of energy in human life as they are widely present in all living organisms. For example they act as post-translational modification of proteins in particular in signal transduction. Furthermore OPCs have wide-spread biological activities and many of these compounds are analogues of natural products and act as pro-drugs. For instances they showed to be good pharmacophore based drug design such as antibacterial and antifungal anticancer antiviral antihypertensive antitubercular and bone seeking agents.