<p>For centuries nature has been an inspirational source for the discovery of drugs used in modern medicine. Nowadays natural-based treatments continue to be employed for primary health care particularly playing a significant role in folk medicine. In addition we are currently observing an increasing use of natural-products-based supplements from botanical and marine sources making their standardization and scientific validation a priority to guarantee the safety of these products. Natural products and/or synthetic derivatives using their novel structures have also been of utmost importance in drug discovery and development in several clinical areas. After a period of discreditation and reduced investment we are now witnessing a renewed interest from the pharmaceutical industry and scientific community due to the urgent need to develop new drugs. This reprint comprises 11 original and 6 review articles dedicated to plant and marine natural products research contributing to the scientific validation of their use and opening new perspectives in drug discovery</p>
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