<p>This Special Issue of <em>Life</em> entitled Plants as a Promising Biofactory for Bioactive Compounds showcases the latest research that explores the utilization of plant biofactories for&nbsp;the production of&nbsp;compounds with multiple biological effects including antioxidant antitumor antidiabetic anti-inflammatory antimicrobial anti-Alzheimer antihemolytic neuroprotective and pesticide activities.</p>