Plasma free amino acids changes in HCC patients

The aim of the book is to investigate plasma free amino acids profile as a possible diagnostic/prognostic factor in hepatocellular carcinoma patients. This study included 71 Hepatocellular cacinoma patients and 30 chronic HCV patients in addition to 30 healthy controls. Laboratory investigations including; complete blood picture liver function tests serum alpha fetoprotein hepatitis viral markers. The book showed a statistically significant increase of methionine tyrosine ornithine citrulline glycine phenylalanine alanine glutamate proline and arginine and decrease of valine aspartate leucine/isoleucine BTR and fischer ratio in hepatocellular carcinoma compared to control group. Also it indicated that there was a statistically significant correlation between BTR and platelets alanine transaminase albumin bilirubin and alpha fetoprotein and significant differences in BTR among Child-Pugh A B and C. Our results suggested that the plasma free amino acids profile is considered valuable for diagnosis and nutritional care in cancer patients.Furthermore BTR reflects the pathological liver background with a high degree of correlation to other liver functional markers.