<p>In 2020 the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus) led to the worst worldwide healthcare crisis of this century. Several publications regarding the pathogenesis and etiology of SARS-CoV-2 virus have enahnced our understanding of coronavirus disease 2019 (COVID-19) the condition provoked by SARS-CoV-2. Once the COVID-19 pandemic ended clinicians and researchers were faced with the long-lasting consequences of this condition namely the presence of symptoms persisting years after the main infection; this has been named long-COVID or post-COVID-19 condition. In fact it is estimated that millions of COVID-19 survivors will be long haulers. This Special Issue in the <em>Journal of Clinical Medicine</em> entitled Post-COVID Symptoms in Long-Haulers: Definition Identification Mechanisms and Management-Part II focuses on the identification underlying mechanisms and mangement of long-COVID. The thirteen papers published in this Special Issue address heterogeneous topics such as risk factors long-term prevalence data the healthcare burden medical co-morbidities clinical trials concerning rehabilitation treatments and data concerning children with long-COVID.</p>