This practical manual will helpful for the students of Genetics and Plant Breeding. It has a number of exercises alongwith examples and problems related to course content. It contents excercise viz. Study of microscope Study of cell structure practice on mitotic cell division experiment on monohybrid dihybrid trihybrid back cross and test cross epistatic interactions - I II and III. Experiments on probability Chi-Square test determination of linkage and cross over analysis Study on sex linked inheritance in Drosophila and Study of models on DNA and RNA structure.