Preparation Physicochemical Characterization

The present study is an attempt to modulate the antioxidant efficacy of natural phenolic compound curcumin with an intention to improve its otherwise poor bioavailability. With this viewpoint novel biocompatible nanoemulsions with four different surfactants namely SDS DTAB poloxamer and Tw-20 have been prepared using ethanol and glycerol as co-solvent and co-surfactant respectively. The bionanoemulsions were therefore prepared in blank as well as with drug loaded forms at a concentrative extent of 3 mM/mL. The drug loaded as well as blank bionanoemulsions thus prepared have been thermodynamically characterized for physicochemical properties of surface tension viscosity density sound velocity and conductivity measurement to quantitatively determine the drug loading efficacy. The characterization with respect to proper and homogeneous drug dispersion has also been investigated via DLS-Dynamic Light Scattering. Alongside the RSAs with DPPH-free radical assay have also been determined and confirmed through UV-visible spectroscopy. The in-vitro drug release potency has thus been explained and highlighted.