Proanthocyanidin against convulsion and cognitive impairment

Convulsive status epilepticus is arguably one of the most debilitating neurological disorder characterized by prolong episode of seizures. It is worthy of note that brain diseases pose the largest health economic and social capital burden worldwide of any disease group. This study has explored the potential effects of proanthocyanidin rich fraction (PRF) obtained from grape seed on the central nervous system particularly in convulsive status epilepticus (CSE) model. In this study a significant brain and hippocampus atrophy increased malondialdehyde concentration increased hippocampus glial cells and granule count exacerbated activities of acetylcholinesterase and increased indices of neuroinflammation following CSE induction are consistent with the hippocampus-dependent memory impairment observed observed among the convulsed mice. However most of these aberrations including alteration of cholinergic neurotransmitters astrogliosis hippocampus toxicity neuroinflammation and neuronal necrosis were ameliorated following PRF treatment a result similar to what was obtainable in the group treated with a standard drug diazepam.