Process model adaption

Bioprocesses in which gases serve as substrates have become popular in the past years as they are used for example to upgrade industrial exhaust gases. In this book first a regulatory concept for the autotrophic cultivation of the bacterium Ralstonia eutropha is presented. The focus lies on a model-based gas phase controller that works independently of the strain. It adjusts the gas composition in the reactor headspace and maintains the desired excess pressure. The gas phase controller is framed by the general model-based control system for process optimization. The second part deals with rapid model adaption for genetically modified strains. For process optimization strain-dependent process models are used. Thus the general process model has to be modified and reformulated for each strain before it can be utilized for model-based optimization. In order to shorten the labour-intensive iterative step of modeling different adaption methods were developed and applied. The combination of a strain-independent gas phase control and a toolbox for fast adaption of the process model of genetically modified strains enables a fast and resource-saving process adaption.