Psoriasis

This book illustrate the predictive value of TNF–αIL-18CRPand Osteopontin Role as biomarkers for monitoring disease prognosis and response to therapy.Inflammatory and dyslipidemia biomarkers used in this study confirmed that psoriasis are at risk factor for development of CVD and the earliest biomarker with significant predictivity was IL-18 as it was with significant AUC values for duration age disease severity and BMI. However TNF-α was early significant risk factor for age and obesity while HDL was early significant risk factor for obesity and age. In addition OPN serum level was with early risk factor with significant predictivity was disease duration and age while CRP with early predictive value in obesity. Furthermore LDL and NHDL were with early risk factor significant predictivity was obesity while for lipid profile ratesTG/HDL was disease severity obesity and disease duration;NHDL/HDL LDL/HDL and TC/HDL was obesity.Serum TNF αIL-18Osteopontin and lipid profile were increased in psoriasis may reflect risk factor for development of CVD in such population.IL-18TNF-αand CRP polymorphism play a role in Pathogenicity and susceptibility to psoriasis and MI.