This quantitative study identifie factors affecting tourist perception in the context of rural tourism in Ca Mau province – the southernmost province of Vietnam belonging to the Mekong Delta. In which local culture infrastructure and marketing communication has positive relation with tourist perception while services & entertainment has negative relation. The research produced 400 structured questionnaires to collect data on these factors in Ca Mau and found that there is a significant influence on tourist perception in rural tourism sector which 58% changing in tourist perception is explained by the independent variables.