Reactivity of cyclododecanone in aldol and Mannich-Type reactions

In this book we address cyclododecanone as a substrate-controlled precursor. Its unique activation strategy acting cooperatively with Lewis based or Lewis acid groups has been applied to the development of a novel generation of cyclododecanone based compounds. The viability of the catalyst under optimized reaction condition was established for all the title reactions. Extended mechanistic pathways lead to the suggestion of a catalytic cycle in which highly preferred transition state plays a major role for both yield and diastereoselectivity for the reactions. Finally strategies were employed to further examine asymmetric induction reaction in cyclododecanone using proline as a catalyst but we could not achieve goals at present conditions. Even unmodified ketone like propiophenone the stereochemistry has been thoroughly investigated. Whereas higher cyclic ketones like 9-12 membered ring cyclic ketones the stereochemistry has not been studied so far. The aim of our work is to studied the reactivity of CDD in aldol sequences and Mannich-type reaction in direct manner and to know the stereochemical behavior of higher ring ketones.