<p>Pancreatic neoplasms include different pathological entities with variable biological behavior and different treatment modalities. Surgery and adjuvant therapy are the cornerstones of the therapeutic approach; however even after radical resection the majority of patients experience disease recurrence and the prognosis of pancreatic cancer remains dismal. </p><p>&nbsp;</p><p>A multimodal therapeutic approach based on a combination of neoadjuvant therapy chemotherapy radiotherapy immunotherapy and surgery appears fundamental to improving the outcomes.</p><p>&nbsp;</p><p>This Special Issue of the <em>Journal of Clinical Medicine</em> entitled Recent Advances in Pancreatic Neoplasms focuses on possible new strategies to treat pancreatic neoplasms.</p>