Recent Approaches for Enhancing the Solubility of Drugs

Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. It is generally recognized that poor solubility is one of the most frequently encountered difficulties in the field of pharmaceutics. Low solubility and subsequent unsatisfactory dissolution rate are often compromise with the oral bioavailability of drugs. This article demonstrates the various techniques which are used to enhance the aqueous solubility which can thus be a valuable aid to increase the efficiency and reducing side effect for the drugs. Hence various techniques are used for the improvement of the solubility of poor water soluble drugs which include Hydrotropy pH adjustment Cosolvency Misceller solubilization Supercritical fluid techniques Solid dispersion Complexation Microemulsion use of surfectants and Nanonization.