Role of HPIP a cytoplasmic regulator of ER-Alpha in microtubule dynamics

Master's Thesis from the year 2009 in the subject Chemistry - Bio-chemistry grade: 9.12 course: Medical Biotechnology - Protein Biochemistry language: English abstract: Cancer being a complex disease is well implicated to deregulated activity of numerous cellular proteins ultimately accounting for functions of cell division and survival etc.Molecular oncological evidences point microtubules and their associated proteins called MAPs as one of the most vital proteins to elicit tumour malignancy at the cellular level.In this dissertation a MAP protein called HPIP has been investigated for its role in polymerization of cytoskeleton microtubules and cancer disease progression.Preliminary lines of experiment conducted under in vitro conditions enabled us to interpret HPIP as a factor promoting the polymerization of microtubules the head apparatus for chromosomal congression and segregation during real time cell division.