ROLE OF THE MODULATING FACTORS ON THE PHENOTYPE OF SICKLE CELL DISEASE

Sickle cell first reported by James B Herrick; (Herrick 1910) a Chicago cardiologist and professor of medicine United States in red blood cells. The disease was named sickle-cell anaemia by Verne Mason in 1922 then a medical resident at Johns Hopkins Hospital.(Konotey-Ahulu 2004) However some elements of the disease had been recognized earlier: A paper in the Southern Journal of Medical Pharmacology in 1846 described the absence of a spleen in the autopsy of a runaway slave.