This book is focused on the development of newer non-steroidal anti-inflammatory agents (NSAIAS) which could establish as newer promising NSAIDS. Synthesis of new heterocycles viz. thiazoles pyrazoles and 2 4-thiazolidinone-diones possessing COX-2 selective methyl sulphonamide pharmacophore by rational drug design approach is reported. In vitro and in vivo anti-inflammatory screening data of synthesized compounds is recorded.
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