Selected Papers from the pHealth 2021 Conference Genoa Italy 8-10 November 2021

<p>This reprint addresses healthcare transformation towards personalized participative preventive predictive and precision medicine (5P Medicine) with the support of new technologies such as micro- nano- and bio-techniques as well as artificial intelligence and learning systems. It focuses therefore on the representation and management of knowledge from different domains and their actors using their methodologies and languages but also individual skills and experiences. The outcome is a system-oriented architecture-centric ontology-based policy-driven approach allowing a formal representation and management of health ecosystems including their integration and interoperability. Such development is accompanied by security privacy and ethical challenges to be resolved. The reprint describes the principles methodologies and standards for successfully managing the transformation of health and social care illustrated by many practical examples and implemented use cases. The reprint is based on papers published in the context of the pHealth 2021 Conference in Genoa Italy. However the content goes far beyond the focus and size of the original papers.</p>