Serum levels of soluble RANKL in patients with DISH and AS

S-RANKL has been identified to control bone regeneration and remodeling. Methods: S-RANKL is estimated on 55 patients with Diffuse Idiopathic Skeletal Hyperostosis (DISH) 25 patients with Ankylosing Spondilitis (AS) 50 patients with spondylosis and 15 particularly healthy people aged 55-65. The measuring of the S-RANKL is done by ЕLISA-method Results:The average measurements of s-RANKL of patients with DISH were 19700±3590 pg/ml in patients with AS 19086±1854 pg/ml. S-RANKL in patients with spondilosis were 2060±6616 pg/ml and in old control group were 2333±1507 pg/ml. The average measurements of s-RANKL in patients with DISH and AS were significant higher in comparison with the results of patients with spondylosis and healthy people regardless of their age (p<0.05). Conclusion: S-RANKL is significantly increased in patients with DISH and spondylosis in comparison with the results of patients with AS and healthy old people. Hypothetically this might be a result as a sequence of events based on stimulation of inflammatory proteins on-going osteoporosis and compresion fractures in patients with DISH and spondylitis.