Single-Arm Phase II Survival Trial Design

<p>Single-Arm Phase II Survival Trial Design provides a comprehensive summary to the most commonly- used methods for single-arm phase II trial design with time-to-event endpoints. Single-arm phase II trials are a key component for successfully developing advanced cancer drugs and treatments particular for target therapy and immunotherapy in which time-to-event endpoints are often the primary endpoints. Most test statistics for single-arm phase II trial design with time-to-event endpoints are not available in commercial software. </p><p>Key Features:</p><ul> <p> </p> <li>Covers the most frequently used methods for single-arm phase II trial design with time-to-event endpoints in a comprehensive fashion.</li> <p> </p> <li>Provides new material on phase II immunotherapy trial design and phase II trial design with TTP ratio endpoint.</li> <p> </p> <li>Illustrates trial designs by real clinical trial examples </li> <p> </p> <li>Includes R code for all methods proposed in the book enabling straightforward sample size calculation.</li> </ul>