Solubility Enhancement of Poorly Water-Soluble Drugs using Mixed Solvency Approach

Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. There are many techniques which are used to enhance the aqueous solubility. The ability to increase aqueous solubility can thus be a valuable aid to increasing efficiency and/or reducing side effects for certain drugs. This is true for parenterally topically and orally administered solutions. Hydrotropy is one of the solubility enhancement techniques which enhance solubility to many folds with use of hydrotropes     like sodium benzoate sodium citrate urea niacin amide it does not require chemical modification of hydrophobic drugs use of organic solvents or preparation of emulsion system etc.