Solving the Puzzle

<p>Inflammatory bowel disease (IBD) encompasses chronic idiopathic relapsing and remitting gastrointestinal autoimmune diseases characterized by chronic inflammatory disorders of complex etiology posing clinical challenges due to their often therapy-refractory nature. The primary disorders within the IBD classification are ulcerative colitis (UC) and Crohn's disease (CD) sharing similarities but exhibiting distinct differences sometimes making their discrimination challenging.</p><p>A prominent feature of IBD is the inflammation of the intestinal mucosa characterized by the robust and persistent infiltration of immune cells and compromised intestinal barrier integrity leading to a phenomenon known as leaky gut. Inflammation can manifest acutely or chronically known as relapsing and can increase in severity over time thereby causing life-long morbidities and reduced quality of life for affected individuals underscoring the need for a deeper comprehension of the molecular contributors to disease pathogenesis and progression.</p>