The parameters of e-commerce are constantly evolving necessitating the need for continuous research. Also despite existing remarkable theories on entrepreneurship prerequisites for business start-ups in a developing economy may differ from other large-scaled and worldwide markets. This is the reason why the research conducted in a confined economy such is Greece. A comprehensive survey through questionnaires to e-customers and interviews to e-entrepreneurs in Greece has clarified these prerequisites for e-commerce business leading to various interesting results that can be used by today’s business society.