Stereoselective Syntheses of Tetrahydropyrans

In his thesis Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A (+)-dactylolide and (±)diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions such as those discussed by Lee has the potential to impact natural product synthesis pharmaceutical development and chemical biology.