Structural Biology Of CFTR

The cystic fibrosis transmembrane conductance regulator (CFTR) is a transmembrane protein that functions as an ion channel. Mutations in this protein cause Cystic Fibrosis. For this reason it is important to study the structure and function of CFTR. In this book constructs of CFTR (C-terminii) a CFTR-interacting protein and full-length CFTR will be investigated in terms of DNA cloning expression and purification for structural and functional studies.